Histamine Intolerance in Children: A Narrative Review

Histamine intolerance is defined as a disequilibrium of accumulated histamine and the capacity for degradation. This clinical term addresses non-immunologically mediated pathology when ingested with food not particularly high, however its degradation decreased. paper aims to provide narrative review on etiopathology, epidemiology, possible diagnostic algorithms challenges in children. The picture children similar that observed adults apart from male predominance found paediatric patients. Both adults, histamine-reduced diet typically treatment choice. Diamine oxidase supplementation offers another option. There no symptom or test pathognomonic intolerance. Nevertheless, manifestations chronic gastrointestinal symptoms, measurements diamine deficits, positive results provocation tests improvement symptoms considerably increase probability diagnosis. These factors have been included proposed algorithm In most likely co-occurs allergies bowel diseases, which creates an additional challenge. As evidence poor further research needed determine validate establish options regarding